The interplay between genetic variances within the TPMT and NUDT15 genes and drug metabolism is profound. It markedly increases the chance of drug toxicity when individuals are administered standard thiopurine doses. This underscores the critical role of preemptive genetic testing for TPMT and NUDT15. It is pivotal in ensuring safer pharmacotherapeutic approaches and tailoring care solely to patient-specific requirements.
Key Takeaways:
Preemptive genetic testing for TPMT and NUDT15 is crucial in optimizing thiopurine treatment.
Variants in the TPMT and NUDT15 genes can lead to an accumulation of harmful metabolites and increase the risk of toxicity.
Clinical implementation of TPMT and NUDT15 testing has shown positive outcomes, improving patient care.
Understanding TPMT and NUDT15 genetic variations can guide medication selection and dosing, ultimately improving patient outcomes.
Genetic testing plays a vital role in personalized med...
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