Pharmacogenomics (PGx) is entering a new phase of growth. What began as a niche offering in clinical genetics is now becoming a critical component of personalized medicine, especially in primary care, psychiatry, oncology, and chronic disease management. In 2025, the industry is shifting its focus toward practical, system-wide challenges like payer adoption, clinical workflow integration, equitable access, and real-world utility.
A new wave of startups is stepping in to meet these needs. These companies are not only advancing the science behind gene-drug interactions but are also building the tools, platforms, and partnerships required to bring PGx into everyday healthcare. From AI-driven prescribing support to implementation services for hospitals and employers, these startups are shaping the future of how PGx is delivered and paid for.
Here are 10 PGx startups making moves in 2025 and why they deserve your attention.
1. UGenome AI
HQ: Green Valley, Arizona, USA
Focus: AI-driven genomic analysis and personalized pharmacogenomics
UGenome AI is a precision medicine company transforming how clinicians interpret whole genome sequencing data. Its flagship platform uses advanced bioinformatics and artificial intelligence to extract pharmacogenomic insights directly from WGS and WES datasets. This eliminates the need for additional testing while accelerating personalized treatment planning.
One of UGenome AI’s core innovations is the generation of personalized reference genomes, which allow for more accurate variant calling and clinical interpretation. Their technology is designed to make genomic data immediately actionable, particularly in complex or rare disease cases where timely decision-making is critical.
In 2025, UGenome AI expanded its reach through strategic partnerships that integrate PGx testing into its software workflow. By combining clinical-grade pharmacogenomic data with AI-powered interpretation tools, the company is helping healthcare providers deliver safer, more effective medication strategies—tailored to each patient’s genetic profile.
UGenome AI is part of a growing movement that sees artificial intelligence not just as a support tool, but as a central engine for making personalized medicine scalable, accessible, and clinically relevant.
2. Peregrine WORx
HQ: USA
Focus: Pharmacogenomics-driven wellness and personalized care
Peregrine WORx is redefining how people access and benefit from pharmacogenomics. The company offers a subscription-based wellness service that uses your genetic profile to guide medication decisions and support long-term health. Instead of providing a one-time test result, Peregrine WORx stays with the patient, offering continuous access to insights and recommendations through a secure, HIPAA-compliant platform.
What sets Peregrine WORx apart is its focus on personalization and patient control. Clients can choose to share their genetic and clinical data with healthcare providers, pharmacists, or care teams, ensuring that decisions are informed and collaborative. The service is designed to be accessible and proactive, helping individuals make better choices about their medications, supplements, and overall wellness.
By merging precision medicine with ongoing support, Peregrine WORx is creating a more patient-centered model of care—one that puts genomics to work in everyday life.
3. RxOptimization
HQ: USA
Focus: Pharmacogenomic consultation and medication management
RxOptimization, led by pharmacist Dr. Patricia Camazzola, delivers real-world pharmacogenomic support with clarity and confidence. She guides patients and their healthcare providers through genetic test interpretations within a comprehensive medication management framework. Every consultation starts with a patient’s medication history—including prescriptions, over-the-counter drugs, and supplements—so recommendations feel personalized and relevant.
RxOptimization blends genetic insights with clinical context. Dr. Camazzola reviews test results alongside patient history and goals to advise medication changes that are safe and effective. Since every session happens via phone or video, timing stays flexible and accessible.
By combining pharmacogenomics with medication optimization, RxOptimization ensures each prescription aligns with an individual’s genetic profile and unique health needs.
4. Gene by Gene
HQ: Houston, Texas
Focus: Clinical-grade pharmacogenomics and genomic services
Gene by Gene serves as both a consumer and a clinical testing platform. While widely recognized as the parent company of FamilyTreeDNA, it also operates a CAP‑accredited clinical laboratory that provides pharmacogenomic panels and other genetic testing services. Their infrastructure supports direct testing for individual patients and robust B2B partnerships with healthcare providers, research institutions, and other labs.
By maintaining high clinical standards and leveraging broad testing capabilities, Gene by Gene enables seamless integration of PGx into clinical and commercial workflows.
5. GenXys Health Care Systems
HQ: Vancouver, Canada
Focus: PGx-powered clinical decision support for real-time prescribing
GenXys Health Care Systems combines pharmacogenomics with clinical workflow. Their platform embeds genetic insights directly into electronic health record systems, helping providers make smarter prescribing choices right at the point of care. By translating gene-drug interactions into clear, evidence-based guidance, they empower primary care clinicians, pharmacists, and health system teams to act with confidence.
Their technology brings precision medicine into everyday practice. GenXys helps healthcare professionals interpret complex genetic data without slowing clinical operations. The platform offers seamless decision support, grounded in clinical evidence and designed for real-world use.
6. Telos PGx
HQ: Addison, Texas, USA
Focus: Pharmacogenetic testing for senior care, home health, physicians, and laboratories
Telos PGx delivers personalized pharmacogenomic testing with a focus on accessibility and clinical relevance. The company serves a wide range of healthcare channels, including skilled nursing facilities, home-based care, physicians, and partner laboratories. Its goal is to support safer prescribing by helping care teams match medications to each patient’s genetic profile.
Through its work in senior care, Telos PGx helps reduce adverse drug reactions and improve resident outcomes. Physicians receive clear, clinically actionable reports that guide decision-making, while labs can partner with Telos to expand their testing menus without building infrastructure from scratch.
The company’s strength lies in its ability to meet the needs of diverse care environments. Whether working with a long-term care facility or a remote patient, Telos PGx ensures that pharmacogenomics becomes a useful part of routine care.
7. Corriel Life Sciences
HQ: New Jersey, USA
Focus: Building the infrastructure for pharmacogenomics programs
Corriel Life Sciences helps healthcare organizations and laboratories launch customized pharmacogenomics initiatives under their own brand. The company supports every step of program development, from patient education materials to clinical protocol design and compliance documentation. Corriel aims to turn pharmacogenomics from a complex scientific concept into a scalable and operational clinical service.
Their services streamline the process for institutions to start or expand PGx services. Instead of building everything in-house, organizations can rely on Corriel’s frameworks to deliver personalized medicine efficiently.
8. Kailos Genetics
HQ: Alabama, USA
Focus: Customizable PGx panels and scalable SaaS tools
Kailos Genetics brings precision medicine into reach through its customizable sequencing technology and analytics platform. Labs, clinics, and health systems can build pharmacogenomic panels tailored to their clinical goals. Users have the option to integrate Kailos’ tools into existing workflows or utilize their CAP-accredited, CLIA-certified laboratory for testing and analysis.
Their platform pairs targeted enrichment sequencing with high-powered analytics. This makes comprehensive genetic insights accessible and actionable for research and clinical use. Kailos supports the full journey—from assay design to data interpretation—giving partners a seamless, end-to-end solution.
By combining flexible panel design, rigorous clinical standards, and robust analytical infrastructure, Kailos Genetics helps organizations deliver tailored precision medicine programs with speed and confidence.
9. ActX
HQ: Seattle, USA
Focus: EHR-integrated pharmacogenomic alerts
ActX makes PGx recommendations a seamless part of clinical care by embedding real-time alerts directly into electronic health record systems such as Epic and Cerner. Providers receive actionable guidance at the point of decision-making, empowering them to choose medications and dosing tailored to a patient’s genetic profile. This integration transforms pharmacogenomics from a separate report into a practical, everyday tool for safer prescribing and better outcomes.
10. Cygenex
HQ: Florida, USA
Focus: PGx solutions for employers, brokers, and Medicare plans
Cygenex partners with payers and insurance brokers to make pharmacogenomic testing a strategic part of healthcare risk management. Their turnkey platform delivers everything from test logistics and provider education to robust health economics insights. By focusing on high-cost patient populations, Cygenex helps organizations optimize medication strategies, improve outcomes, and demonstrate clear return on investment. Their full-service model turns PGx from a technical option into a practical tool for cost-effective, personalized care.
Conclusion
As pharmacogenomics continues to gain traction in clinical and commercial settings, these startups are playing a key role in shaping how it reaches patients. Each company featured here is addressing a specific challenge in the PGx value chain—whether through technology, education, clinical integration, or payer alignment. Their efforts signal a broader shift toward making personalized prescribing the standard, not the exception. For anyone watching the future of precision medicine, these are the companies to keep an eye on.
